Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 6/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 3/20 | 0.34 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140941 | 0.81 | GRM1 (0.46) | GRM1CYP2D6GSK3BDRD4DRD2 | |
| SCHEMBL20139834 | 0.79 | GRM1 (0.41) | GRM1CYP2D6GSK3BDRD4HTR7 | |
| SCHEMBL20140721 | 0.73 | GRM1 (0.45) | GRM1DPP4MTORRPTORMLST8 | |
| SCHEMBL20157490 | 0.73 | GRM1 (0.45) | GRM1DPP4MTORRPTORMLST8 | |
| SCHEMBL20140644 | 0.72 | GRM1 (0.42) | GRM1CYP2D6GSK3BDRD2HTR7 | |
| SCHEMBL20140416 | 0.72 | GRM1 (0.43) | GRM1DRD4MTORRPTORMLST8 | |
| SCHEMBL20156987 | 0.72 | GRM1 (0.43) | GRM1DRD4DRD2DRD3MTOR | |
| SCHEMBL31155326 | 0.71 | GRM1 (0.43) | GRM1CYP2D6GSK3BDRD4DRD2 | |
| SCHEMBL20140731 | 0.70 | DRD4 (0.54) | CYP2D6DRD4DRD2DRD3HTR7 | |
| SCHEMBL30607698 | 0.69 | GRM1 (0.54) | GRM1CYP2D6GSK3BDRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |