Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.51 |
| ▸ | OTC | P00480 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.35 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | ARG1 | P05089 | 3/20 | 0.35 |
| ▸ | ARG2 | P78540 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL10277141 | 0.85 | GLRA1 (0.36) | — | |
| Lysine SCHEMBL2015695 | 0.81 | GSR (0.48) | GSROTCTHRBARG1ARG2 | |
| Lysine SCHEMBL3418558 | 0.79 | GSR (0.62) | GSRTHRBARG1ARG2 | |
| Lysine SCHEMBL3418555 | 0.79 | GSR (0.62) | GSRTHRBARG1ARG2 | |
| Glutamine SCHEMBL6858577 | 0.79 | ALOX15 (0.54) | GSRGRM8GRM6GRM7GRM4 | |
| Lysine SCHEMBL23292473 | 0.78 | GSR (0.65) | GSRTHRBGRM8GRM6GRM7 | |
| Lysine SCHEMBL8322630 | 0.78 | GSR (0.65) | GSRTHRBGRM8GRM6GRM7 | |
| Lysine SCHEMBL5011625 | 0.77 | GSR (0.74) | GSRTHRBGRM8GRM6GRM7 | |
| Lysine SCHEMBL4259257 | 0.77 | GSR (0.74) | GSRTHRBGRM8GRM6GRM7 | |
| Lysine SCHEMBL5493896 | 0.77 | GSR (0.74) | GSRTHRBGRM8GRM6GRM7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8244484-B2 | Proteome epitope tags and methods of use thereof in protein modification analysis | EMD MILLIPORE CORPORATION (US) | 2012-08-14 | — | — | US | disclosed |
| US-7964362-B2 | Proteome epitope tags and methods of use thereof in protein modification analysis | MILLIPORE CORPORATION (US) | 2011-06-21 | — | — | US | disclosed |
| US-20100331200-A1 | POST TRANSLATIONAL MODIFICATION PATTERN ANALYSIS | MILLIPORE CORPORATION | 2010-12-30 | — | — | US | disclosed |
| US-20100184613-A1 | Proteome Epitope Tags and Methods of Use Thereof in Protein Modification Analysis | MILLIPORE CORPORATION (US) | 2010-07-22 | — | — | US | disclosed |
| US-7618788-B2 | Proteome epitope tags and methods of use thereof in protein modification analysis | MILLIPORE CORPORATION (US) | 2009-11-17 | — | — | US | disclosed |
| US-20090023157-A1 | Proteome epitope tags and methods of use thereof in protein modification analysis | EMD MILLIPORE CORPORATION | 2009-01-22 | — | — | US | disclosed |
| US-7460960-B2 | Proteome epitope tags and methods of use thereof in protein modification analysis | EPITOME BIOSYSTEMS, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| WO-2007123708-A2 | POST TRANSLATIONAL MODIFICATION PATTERN ANALYSIS | EPITOME BIOSYSTEMS, INC. (US) | 2007-11-01 | — | — | WO | disclosed |
| EP-1683065-A2 | PROTEOME EPITOPE TAGS AND METHODS OF USE THEREOF IN PROTEIN MODIFICATION ANALYSIS | Epitome Biosystems, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| US-20060014212-A1 | Proteome epitope tags and methods of use thereof in protein modification analysis | EPITOME BIOSYSTEMS, INC. (US) | 2006-01-19 | — | — | US | disclosed |
| WO-2005078453-A2 | PROTEOME EPITOPE TAGS AND METHODS OF USE THEREOF IN PROTEIN MODIFICATION ANALYSIS | EPITOME BIOSYSTEMS INC. (US) | 2005-08-25 | — | — | WO | disclosed |
| WO-2005050223-A2 | PROTEOME EPITOPE TAGS AND METHODS OF USE THEREOF IN PROTEIN MODIFICATION ANALYSIS | EPITOME BIOSYSTEMS INC. (US) | 2005-06-02 | — | — | WO | disclosed |
| US-20050069911-A1 | Using peptide probes to for high sensitivity/accuracy in detection quantitation of target proteins; biosignatures and disease diagnosis | ENGENEOS, INC. (US) | 2005-03-31 | — | — | US | disclosed |
| US-20040180380-A1 | Proteome epitope tags and methods of use thereof in protein modification analysis | ENGENEOS, INC. | 2004-09-16 | — | — | US | disclosed |