Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | FABP6 | P51161 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157034 | 0.91 | NPC1 (0.42) | NPC1MYCFABP6MTORRPTOR | |
| SCHEMBL20157303 | 0.90 | MTOR (0.42) | NPC1MYCFABP6MTORRPTOR | |
| SCHEMBL20157082 | 0.90 | MYC (0.54) | MYCALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL20156994 | 0.86 | KDM4E (0.54) | MTORRPTORMLST8ALDH1A1HTR7 | |
| SCHEMBL20140323 | 0.86 | KDM4E (0.54) | MTORRPTORMLST8ALDH1A1HTR7 | |
| SCHEMBL20157037 | 0.84 | SLC6A7 (0.52) | MYCMEN1KMT2AKDM4E | |
| SCHEMBL20140023 | 0.83 | MTOR (0.61) | MTORRPTORMLST8ALDH1A1HTR7 | |
| SCHEMBL20157349 | 0.83 | NPC1 (0.41) | NPC1FABP6MTORRPTORMLST8 | |
| SCHEMBL20139966 | 0.83 | MTOR (0.61) | MTORRPTORMLST8ALDH1A1HTR7 | |
| SCHEMBL20140797 | 0.83 | KDM4E (0.58) | MTORRPTORMLST8ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |