Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.40 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FABP6 | P51161 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157034 | 0.93 | NPC1 (0.42) | NPC1MTORRPTORMLST8SMN1; SMN2 | |
| SCHEMBL20157078 | 0.85 | MYC (0.47) | LMNASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL20157035 | 0.83 | NPC1 (0.46) | NPC1MTORRPTORMLST8LMNA | |
| SCHEMBL20157303 | 0.83 | MTOR (0.42) | NPC1MTORRPTORMLST8LMNA | |
| SCHEMBL20140323 | 0.80 | KDM4E (0.54) | MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL20156994 | 0.80 | KDM4E (0.54) | MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL20156914 | 0.77 | MYC (0.46) | LMNASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL20157082 | 0.77 | MYC (0.54) | LMNASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL20140023 | 0.77 | MTOR (0.61) | MTORRPTORMLST8ALDH1A1ENPP2 | |
| SCHEMBL20139966 | 0.77 | MTOR (0.61) | MTORRPTORMLST8ALDH1A1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |