Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | CALCA | P06881 | 1/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TXK | P42681 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156826 | 0.86 | MTOR (0.46) | MTORRPTORMLST8HTR1AMEN1 | |
| SCHEMBL20156828 | 0.77 | MTOR (0.54) | MTORRPTORMLST8HTR1AMEN1 | |
| SCHEMBL20141561 | 0.77 | MTOR (0.43) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20141564 | 0.77 | MTOR (0.43) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20156797 | 0.76 | MEN1 (0.41) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20141016 | 0.74 | MTOR (0.53) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20157052 | 0.73 | MTOR (0.47) | MTORRPTORMLST8HTR1AMEN1 | |
| SCHEMBL20141846 | 0.71 | MTOR (0.59) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20156832 | 0.71 | MTOR (0.59) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20140055 | 0.71 | MTOR (0.46) | MTORRPTORMLST8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |