Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157285 | 0.84 | HDAC10 (0.40) | KDM4ELMNAKDM4AKCNA5HDAC10 | |
| SCHEMBL21362755 | 0.81 | KCNA5 (0.37) | KDM4ELMNAKDM4AKCNA5HDAC10 | |
| SCHEMBL20157334 | 0.77 | PRMT5 (0.48) | KDM4ELMNAKDM4AKCNA5HDAC10 | |
| SCHEMBL21362444 | 0.76 | PRMT5 (0.43) | KDM4ELMNAKDM4AKCNA5HDAC10 | |
| SCHEMBL13837691 | 0.74 | NAMPT (0.47) | KDM4ELMNAKDM4AHDAC10HDAC6 | |
| SCHEMBL21550130 | 0.74 | KDM4E (0.42) | KDM4ELMNAKDM4AKCNA5HDAC10 | |
| SCHEMBL13837417 | 0.73 | BRD9 (0.47) | KDM4ELMNAKDM4AL3MBTL1NAMPT | |
| SCHEMBL14138610 | 0.72 | GFER (0.46) | KDM4EKDM4AL3MBTL1GFER | |
| SCHEMBL21564983 | 0.72 | KDM4E (0.39) | KDM4E | |
| SCHEMBL21481525 | 0.72 | KCNA5 (0.51) | LMNAKDM4AKCNA5HDAC10HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086605-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |