Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157341 | 0.81 | KDM4E (0.40) | KCNA5KDM4ELMNAKDM4AHDAC10 | |
| SCHEMBL20157285 | 0.78 | HDAC10 (0.40) | KCNA5KDM4ELMNAKDM4AHDAC10 | |
| SCHEMBL20157917 | 0.72 | KDM4E (0.35) | KCNA5KDM4ELMNAKDM4AHDAC10 | |
| SCHEMBL20157334 | 0.71 | PRMT5 (0.48) | KCNA5KDM4ELMNAKDM4AHDAC10 | |
| SCHEMBL21362444 | 0.70 | PRMT5 (0.43) | KCNA5KDM4ELMNAKDM4AHDAC10 | |
| SCHEMBL20157599 | 0.70 | MAPT (0.38) | KCNA5LMNAL3MBTL1RAF1BRAF | |
| SCHEMBL13837691 | 0.69 | NAMPT (0.47) | KDM4ELMNAKDM4AHDAC10HDAC6 | |
| SCHEMBL21550130 | 0.69 | KDM4E (0.42) | KCNA5KDM4ELMNAKDM4AHDAC10 | |
| SCHEMBL20157810 | 0.68 | BRD4 (0.46) | KCNA5KDM4ELMNAKDM4AHDAC10 | |
| SCHEMBL13837417 | 0.68 | BRD9 (0.47) | BAZ2BBAZ2AKDM4ELMNAKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |