Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 3/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157462 | 0.89 | KDM4E (0.40) | GRM1MTORRPTORMLST8DRD4 | |
| SCHEMBL20140941 | 0.87 | GRM1 (0.46) | GRM1MTORRPTORMLST8DRD4 | |
| SCHEMBL20140126 | 0.82 | MTOR (0.53) | MTORRPTORMLST8DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL20140671 | 0.81 | MTOR (0.52) | MTORRPTORMLST8DRD4DRD2 | |
| SCHEMBL20140022 | 0.80 | CHRM2 (0.49) | GRM1MTORRPTORMLST8CHRM4 | |
| SCHEMBL20156791 | 0.79 | MTOR (0.52) | GRM1MTORRPTORMLST8DRD4 | |
| SCHEMBL20139980 | 0.79 | MTOR (0.46) | GRM1MTORRPTORMLST8DRD4 | |
| SCHEMBL20141432 | 0.78 | MTOR (0.50) | MTORRPTORMLST8DRD4DRD2 | |
| SCHEMBL20140782 | 0.78 | CHRM4 (0.44) | MTORRPTORMLST8NOTUMDRD4 | |
| SCHEMBL20140667 | 0.78 | TRPC5 (0.42) | MTORRPTORMLST8DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |