Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.46 |
| ▸ | RET | P07949 | 4/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156791 | 0.92 | MTOR (0.52) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20139970 | 0.82 | GRM1 (0.39) | MTORRPTORMLST8RETGRM1 | |
| SCHEMBL20157050 | 0.80 | MTOR (0.55) | MTORRPTORMLST8RETHCRTR1 | |
| SCHEMBL20157463 | 0.79 | GRM1 (0.41) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20156834 | 0.78 | MTOR (0.54) | MTORRPTORMLST8DPP4 | |
| SCHEMBL20140996 | 0.78 | MTOR (0.44) | MTORRPTORMLST8DRD4DRD2 | |
| SCHEMBL20157462 | 0.77 | KDM4E (0.40) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20139990 | 0.76 | MTOR (0.40) | MTORRPTORMLST8GRM1DRD4 | |
| Trifluoroacetic Acid SCHEMBL20140080 | 0.75 | MTOR (0.42) | MTORRPTORMLST8DRD4DRD2 | |
| SCHEMBL20141544 | 0.75 | MTOR (0.48) | MTORRPTORMLST8RETDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |