SCHEMBL20157705

SCHEMBL20157705

Cc1ccc(C(=O)c2cc(Cl)c(C)cc2Br)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.49
ALDH1A1 P00352 3/20 0.47
LMNA P02545 2/20 0.47
HTT P42858 3/20 0.45
NPC1 O15118 1/20 0.45
MAPK1 P28482 1/20 0.45
CES2 O00748 2/20 0.44
CES1 P23141 2/20 0.44
RXRA P19793 1/20 0.44
AKR1C3 P42330 1/20 0.44
L3MBTL1 Q9Y468 2/20 0.43
RAB9A P51151 1/20 0.43
GAA P10253 1/20 0.43
CNR1 P21554 1/20 0.42
CNR2 P34972 1/20 0.42
SRD5A2 P31213 1/20 0.42
AGTR1 P30556 1/20 0.41
NR4A1 P22736 1/20 0.40
KDM5A P29375 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21362748 0.88 RXRA (0.40) MAPTHTTNPC1MAPK1RXRA
SCHEMBL20157704 0.88 NPC1 (0.44) MAPTALDH1A1LMNAHTTNPC1
SCHEMBL20157492 0.84 MAPT (0.57) MAPTALDH1A1LMNAHTTNPC1
SCHEMBL20157995 0.82 MAPT (0.44) MAPTALDH1A1LMNAHTTNPC1
SCHEMBL20157720 0.82 MAPT (0.44) MAPTALDH1A1LMNAHTTNPC1
SCHEMBL20158002 0.78 MAPT (0.50) MAPTALDH1A1LMNAHTTNPC1
SCHEMBL20157430 0.78 MAPT (0.60) MAPTALDH1A1LMNAHTTNPC1
SCHEMBL20157997 0.77 MAPT (0.40) MAPTALDH1A1LMNAHTTNPC1
SCHEMBL20157979 0.76 MAPT (0.43) MAPTALDH1A1LMNAHTTNPC1
SCHEMBL30294917 0.75 LCK (0.48) MAPTALDH1A1HTTAKR1C3NR4A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018086605-A1 NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF 山东罗欣药业集团股份有限公司 2018-05-17 WO disclosed