Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | STAT5B | P51692 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21362658 | 0.74 | AAK1 (0.35) | HTTCNR2ALDH1A1LMNA | |
| SCHEMBL20158163 | 0.73 | — | — | |
| SCHEMBL21351900 | 0.73 | CNR2 (0.35) | CNR2CA2ALDH1A1LMNAGAA | |
| SCHEMBL20157708 | 0.72 | — | — | |
| SCHEMBL20158166 | 0.69 | MAPT (0.43) | C5AR1MAPTHTTNPC1MAPK1 | |
| SCHEMBL20157584 | 0.68 | CA12 (0.44) | MAPTHTTNPC1MAPK1PPARG | |
| SCHEMBL21352249 | 0.67 | BACE1 (0.34) | HTTCNR2ALDH1A1LMNA | |
| SCHEMBL20157726 | 0.66 | ACHE (0.34) | MAPTHTTALDH1A1LMNA | |
| SCHEMBL21564703 | 0.66 | MAPT (0.33) | MAPTHTTNPC1CNR2CA2 | |
| SCHEMBL11476383 | 0.66 | MAPT (0.51) | MAPTHTTNPC1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086605-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |