SCHEMBL20158425

SCHEMBL20158425

C#CCOCCOCCOCCOCCOCC(=O)N[C@@H](C(=O)NC(CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1)C(C)C

nearest known ligand 0.39

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ FURIN P09958 10/20 0.39
▸ C3AR1 Q16581 1/20 0.38
▸ HTT P42858 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ KLKB1 P03952 3/20 0.34
▸ PSEN1 P49768 2/20 0.33
▸ PSEN2 P49810 2/20 0.33
▸ APH1B Q8WW43 2/20 0.33
▸ NCSTN Q92542 2/20 0.33
▸ APH1A Q96BI3 2/20 0.33
▸ PSENEN Q9NZ42 2/20 0.33
▸ IL23R Q5VWK5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30988370 0.90 FURIN (0.41) FURINC3AR1HTTSMN1; SMN2KLKB1
SCHEMBL30988364 0.90 FURIN (0.42) FURINC3AR1HTTSMN1; SMN2
SCHEMBL22690514 0.86 FURIN (0.41) FURINC3AR1HTTSMN1; SMN2KLKB1
SCHEMBL17637464 0.86 FURIN (0.41) FURINC3AR1HTTSMN1; SMN2KLKB1
SCHEMBL19026283 0.85 FAP (0.38) FURINC3AR1HTTSMN1; SMN2
SCHEMBL19026282 0.85 FAP (0.38) FURINC3AR1HTTSMN1; SMN2
SCHEMBL18931388 0.85 FAP (0.38) FURINC3AR1HTTSMN1; SMN2
SCHEMBL25787504 0.85 FURIN (0.40) FURINC3AR1HTTSMN1; SMN2KLKB1
SCHEMBL15699736 0.85 FURIN (0.40) FURINC3AR1HTTSMN1; SMN2KLKB1
SCHEMBL22138596 0.84 FURIN (0.39) FURINHTTSMN1; SMN2KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11135306-B2 Antibody-drug conjugates CHO Pharma Inc. (TW) 2021-10-05 — — US disclosed
US-20190328895-A1 ANTIBODY-DRUG CONJUGATES CHO Pharma Inc. (TW) 2019-10-31 — — US disclosed
US-20180133340-A1 ANTIBODY-DRUG CONJUGATES CHO Pharma Inc. (TW) 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190328895-A1 ANTIBODY-DRUG CONJUGATES CSGALNACT1, ADCY1, NEU1 FURIN 2375/4885C3AR1 411/4885HTT 2326/4885
US-20180133340-A1 ANTIBODY-DRUG CONJUGATES CSGALNACT1, ST6GAL1, PA2G4 FURIN 3186/4885C3AR1 660/4885HTT 3230/4885
US-11135306-B2 Antibody-drug conjugates CSGALNACT1, ST6GAL1, PA2G4 FURIN 3186/4885C3AR1 660/4885HTT 3230/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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