SCHEMBL20158827

SCHEMBL20158827

COc1ccc2c(c1)c1ccncc1n2Cc1ccc(C)cc1OC

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.50
MAOB P27338 1/20 0.50
HASPIN Q8TF76 2/20 0.47
TP53 P04637 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
ALOX15 P16050 1/20 0.43
STAT6 P42226 1/20 0.43
HIF1A Q16665 1/20 0.43
ACHE P22303 2/20 0.40
GRIN1 Q05586 1/20 0.40
GRIN2A Q12879 1/20 0.40
DYRK2 Q92630 1/20 0.40
KDM4C Q9H3R0 1/20 0.40
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
MAPT P10636 2/20 0.39
MAPK1 P28482 2/20 0.39
BCHE P06276 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20135936 0.84 PLA2G4A (0.49) MAOAMAOBHASPINTP53ACHE
SCHEMBL20135941 0.81 MAOA (0.53) MAOAMAOBHASPINTP53CYP1A2
SCHEMBL20135929 0.79 MAOA (0.51) MAOAMAOBHASPINTP53CYP1A2
SCHEMBL20135898 0.78 MAOA (0.55) MAOAMAOBHASPINKMT2AMAPT
SCHEMBL20147188 0.77 MAOA (0.54) MAOAMAOBHASPINCYP1A2CYP3A4
SCHEMBL20135922 0.74 MAOA (0.47) MAOAMAOBHASPINTP53CYP1A2
SCHEMBL20135935 0.74 MAOA (0.51) MAOAMAOBHASPINTP53CYP1A2
SCHEMBL27351040 0.74 MAOA (0.51) MAOAMAOBHASPINTP53CYP1A2
SCHEMBL27350987 0.73 MAOA (0.50) MAOAMAOBHASPINTP53CYP1A2
SCHEMBL27348493 0.72 MAOA (0.48) MAOAMAOBHASPINTP53CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018087389-A1 SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-kB PATHWAYS MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (DE) 2018-05-17 WO disclosed