Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MPI | P34949 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015850 | 0.85 | L3MBTL1 (0.37) | KDM4ESMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL2012342 | 0.85 | MAPT (0.42) | KDM4ESMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL2163929 | 0.85 | KDM4E (0.43) | KDM4ESMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL2012273 | 0.84 | HTT (0.39) | KDM4ESMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL2014635 | 0.84 | LMNA (0.40) | KDM4ESMN1; SMN2KMT2ATSHRALDH1A1 | |
| SCHEMBL2016487 | 0.83 | GBA1 (0.35) | KDM4ESMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL2017028 | 0.83 | LMNA (0.43) | KDM4ESMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL2013342 | 0.83 | KDM4E (0.52) | KDM4ESMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL2015620 | 0.83 | SMO (0.40) | KDM4ESMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL2013837 | 0.83 | BTK (0.37) | KDM4ESMN1; SMN2MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | claimed |
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |