Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.49 |
| ▸ | SKP1 | P63208 | 2/20 | 0.49 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.49 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.45 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17925972 | 0.88 | CSNK1D (0.41) | CSNK1EHPGDSPRMT5WDR77NR1H2 | |
| SCHEMBL17936827 | 0.85 | CSNK1D (0.44) | CKS1BSKP1SKP2CSNK1EMAPK1 | |
| SCHEMBL25209603 | 0.84 | CSNK1E (0.47) | CKS1BSKP1SKP2CSNK1EGPR119 | |
| SCHEMBL30552384 | 0.84 | CSNK1E (0.47) | CKS1BSKP1SKP2CSNK1EGPR119 | |
| SCHEMBL29707416 | 0.84 | PRMT5 (0.43) | GPR119PRMT5WDR77NR1H2 | |
| SCHEMBL25256810 | 0.82 | PRMT5 (0.42) | CKS1BSKP1SKP2PRMT5WDR77 | |
| SCHEMBL22615344 | 0.81 | MEN1 (0.46) | CKS1BSKP1SKP2MAPK1NR1H2 | |
| SCHEMBL29707324 | 0.81 | MEN1 (0.41) | BACE1NR1H2 | |
| SCHEMBL17936835 | 0.81 | CYP3A4 (0.44) | CSNK1EUSP30PRMT5WDR77NR1H2 | |
| SCHEMBL30913152 | 0.80 | POLB (0.40) | CKS1BSKP1SKP2MAPK1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |