Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29261335 | 0.83 | PRMT5 (0.36) | — | |
| SCHEMBL30625142 | 0.82 | NR1H2 (0.38) | POLBMAPTCKS1BSKP1SKP2 | |
| SCHEMBL20159015 | 0.80 | CKS1B (0.49) | CKS1BSKP1SKP2MAPK1NR1H2 | |
| SCHEMBL18017107 | 0.78 | GRM5 (0.41) | POLBMAPTESR2MAPK1MKNK1 | |
| SCHEMBL17936853 | 0.78 | HPGDS (0.40) | POLBMKNK1NR1H2 | |
| SCHEMBL17936867 | 0.78 | CYP3A4 (0.40) | POLBCCNT1MAPTESR2MKNK1 | |
| SCHEMBL17936827 | 0.78 | CSNK1D (0.44) | MAPTCKS1BSKP1SKP2MAPK1 | |
| SCHEMBL22615360 | 0.77 | CREBBP (0.38) | POLBMAPTCKS1BSKP1SKP2 | |
| SCHEMBL17936879 | 0.76 | CYP3A4 (0.41) | POLBCCNT1ESR2MKNK1CYP3A4 | |
| SCHEMBL17925972 | 0.76 | CSNK1D (0.41) | POLBNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118103369-A | Pyridolactam derivatives, preparation method and application thereof | 浙江海正药业股份有限公司 | 2024-05-28 | — | — | CN | disclosed |