Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.59 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.59 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.59 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | RBP4 | P02753 | 1/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159022 | 0.91 | MTOR (0.58) | MTORRPTORMLST8HTR7RBP4 | |
| SCHEMBL20139263 | 0.90 | MTOR (0.54) | MTORRPTORMLST8HTR7RBP4 | |
| SCHEMBL20159017 | 0.89 | MTOR (0.58) | MTORRPTORMLST8HTR7RBP4 | |
| SCHEMBL20159024 | 0.88 | MTOR (0.64) | MTORRPTORMLST8HTR7RBP4 | |
| SCHEMBL20158902 | 0.88 | MTOR (0.57) | MTORRPTORMLST8HTR7RBP4 | |
| Trifluoroacetic Acid SCHEMBL20140254 | 0.87 | MTOR (0.52) | MTORRPTORMLST8HTR7RBP4 | |
| SCHEMBL20158900 | 0.86 | MTOR (0.56) | MTORRPTORMLST8HTR7RBP4 | |
| SCHEMBL20159109 | 0.81 | MTOR (0.50) | MTORRPTORMLST8HTR7PTGS1 | |
| SCHEMBL20159115 | 0.81 | MTOR (0.55) | MTORRPTORMLST8HTR7PTGS1 | |
| SCHEMBL20159079 | 0.78 | MTOR (0.52) | MTORRPTORMLST8HTR7RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |