Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.50 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20158902 | 0.93 | MTOR (0.57) | MTORRPTORMLST8HTR7 | |
| SCHEMBL20159021 | 0.91 | CACNA1G (0.48) | MTORRPTORMLST8HTR7 | |
| SCHEMBL20159115 | 0.87 | MTOR (0.55) | MTORRPTORMLST8HTR7PTGS2 | |
| SCHEMBL20158900 | 0.85 | MTOR (0.56) | MTORRPTORMLST8HTR7 | |
| SCHEMBL20159116 | 0.83 | MTOR (0.45) | MTORRPTORMLST8HTR7MAPK1 | |
| SCHEMBL20158901 | 0.82 | MTOR (0.62) | MTORRPTORMLST8HTR7TP53 | |
| SCHEMBL20159017 | 0.82 | MTOR (0.58) | MTORRPTORMLST8HTR7PTGS2 | |
| SCHEMBL20159022 | 0.82 | MTOR (0.58) | MTORRPTORMLST8HTR7 | |
| SCHEMBL20159018 | 0.81 | MTOR (0.59) | MTORRPTORMLST8HTR7PTGS2 | |
| SCHEMBL20158898 | 0.81 | MTOR (0.55) | MTORRPTORMLST8HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |