Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.52 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.52 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | GLP1R | P43220 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159152 | 0.85 | MTOR (0.65) | MTORRPTORMLST8DRD4ALDH1A1 | |
| SCHEMBL20159158 | 0.81 | MTOR (0.63) | MTORRPTORMLST8DRD4DRD2 | |
| SCHEMBL20158990 | 0.80 | MTOR (0.77) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20159156 | 0.79 | MTOR (0.64) | MTORRPTORMLST8DRD4ALDH1A1 | |
| SCHEMBL20159155 | 0.79 | MTOR (0.65) | MTORRPTORMLST8DRD4HTR1A | |
| SCHEMBL20159090 | 0.79 | MTOR (0.71) | MTORRPTORMLST8DRD4ALDH1A1 | |
| SCHEMBL20159160 | 0.78 | MTOR (0.61) | MTORRPTORMLST8DRD4HTR1A | |
| SCHEMBL20158993 | 0.78 | MTOR (0.64) | MTORRPTORMLST8DRD4ALDH1A1 | |
| SCHEMBL20159230 | 0.78 | MTOR (0.65) | MTORRPTORMLST8DRD4HTR1A | |
| SCHEMBL20159082 | 0.76 | MTOR (0.75) | MTORRPTORMLST8DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |