Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.51 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.51 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159123 | 0.85 | MTOR (0.69) | MTORRPTORMLST8HRH3DRD2 | |
| SCHEMBL20159036 | 0.85 | MTOR (0.58) | MTORRPTORMLST8HRH3DRD2 | |
| SCHEMBL20159127 | 0.85 | MTOR (0.62) | MTORRPTORMLST8DRD2HTR7 | |
| SCHEMBL20139852 | 0.80 | MTOR (0.49) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20141859 | 0.80 | MTOR (0.49) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20157127 | 0.79 | MTOR (0.49) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20140083 | 0.79 | MTOR (0.49) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20159114 | 0.78 | DRD2 (0.51) | MTORRPTORMLST8HRH3DRD2 | |
| SCHEMBL20140597 | 0.77 | MTOR (0.43) | MTORRPTORMLST8DRD2TACR3 | |
| SCHEMBL20158994 | 0.76 | MTOR (0.53) | MTORRPTORMLST8HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |