Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14836154 | 0.83 | ALDH1A1 (0.54) | ALDH1A1TP53HIF1ASLC6A2SLC6A3 | |
| SCHEMBL4051682 | 0.81 | ALDH1A1 (0.56) | ALDH1A1TP53HIF1ASLC6A2SLC6A3 | |
| SCHEMBL14836137 | 0.80 | ALDH1A1 (0.51) | ALDH1A1TP53HIF1ASLC6A2SLC6A3 | |
| SCHEMBL14835973 | 0.78 | MEN1 (0.67) | ALDH1A1TP53HIF1ASLC6A2SLC6A3 | |
| SCHEMBL7457651 | 0.77 | SMN1; SMN2 (0.47) | ALDH1A1SLC6A2SLC6A3HTTSMN1; SMN2 | |
| SCHEMBL27513862 | 0.77 | PDPK1 (0.55) | ALDH1A1TP53HIF1ASLC6A2SLC6A3 | |
| SCHEMBL15047897 | 0.77 | SMN1; SMN2 (0.57) | ALDH1A1TP53HIF1ASLC6A2SLC6A3 | |
| SCHEMBL28638974 | 0.77 | ALDH1A1 (0.60) | ALDH1A1TP53HIF1ASLC6A2SLC6A3 | |
| SCHEMBL10496871 | 0.75 | ALDH1A1 (0.50) | ALDH1A1TP53HIF1ASLC6A2SLC6A3 | |
| SCHEMBL11235456 | 0.75 | SMN1; SMN2 (0.55) | ALDH1A1TP53HIF1ASLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |