Sugi Predict

Sugi Predict / Compounds / SCHEMBL4051682

SCHEMBL4051682

SCHEMBL4051682

CC(=O)Nc1ccc(C(=O)C(C)Cl)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.56
▸ TP53 P04637 1/20 0.56
▸ HIF1A Q16665 1/20 0.56
▸ SMN1; SMN2 Q16637 4/20 0.53
▸ L3MBTL1 Q9Y468 2/20 0.53
▸ HTT P42858 1/20 0.53
▸ KMT2A Q03164 6/20 0.52
▸ MEN1 O00255 5/20 0.52
▸ MAPT P10636 2/20 0.52
▸ TDP1 Q9NUW8 1/20 0.52
▸ CA12 O43570 1/20 0.52
▸ BRD4 O60885 1/20 0.52
▸ NR1I2 O75469 1/20 0.52
▸ CA1 P00915 1/20 0.52
▸ CA2 P00918 1/20 0.52
▸ MB P02144 1/20 0.52
▸ CYP1A1 P04798 1/20 0.52
▸ CA3 P07451 1/20 0.52
▸ CYP3A4 P08684 1/20 0.52
▸ RARG P13631 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10766624 0.85 GAA (0.54) ALDH1A1SMN1; SMN2L3MBTL1HTTKMT2A
SCHEMBL15047897 0.85 SMN1; SMN2 (0.57) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1
SCHEMBL28638974 0.84 ALDH1A1 (0.60) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1
SCHEMBL11235456 0.83 SMN1; SMN2 (0.55) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1
SCHEMBL10815283 0.81 SMN1; SMN2 (0.53) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1
SCHEMBL6209273 0.81 LMNA (0.54) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1
SCHEMBL15598698 0.81 SMN1; SMN2 (0.53) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1
SCHEMBL9821071 0.81 SMN1; SMN2 (0.53) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1
SCHEMBL20159187 0.81 ALDH1A1 (0.56) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1
SCHEMBL10701976 0.80 SMN1; SMN2 (0.52) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111518081-A Method for synthesizing pimobendan 中国农业大学 2020-08-11 — — CN claimed
JP-1316369-A — — None — — JP disclosed
CN-119409643-A Synthesis and refining method of levosimendan 上药康丽（常州）药业有限公司 2025-02-11 — — CN disclosed
CN-111518081-A Method for synthesizing pimobendan 中国农业大学 2020-08-11 — — CN disclosed
WO-2018086703-A1 DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-05-17 — — WO disclosed
WO-2018086703-A1 DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-05-17 — — WO disclosed
WO-2014043715-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2014-03-20 — — WO disclosed
US-7579352-B2 Retinoic acid mimetic anilides JANSSEN PHARMACEUTICA N.V. (BE) 2009-08-25 — — US disclosed
US-20080058334-A1 Retinoic Acid Mimetic Anilides MABIRE DOMINIQUE 2008-03-06 — — US disclosed
US-20070208036-A1 Arylalkanes, arylalkenes and aryl-azaalkanes, pharmaceutical compositions containing these compounds and processes for preparing them BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2007-09-06 — — US disclosed
US-4877812-A 1-(acetylaminophenyl)-2-aminopropanone derivatives and antidepressant compositions thereof LABORATOIRE L. LAFON (FR) 1989-10-31 — — US disclosed
EP-0174242-B1 1-(AMINO-PHENYL)-2-AMINO PROPANON DERIVATIVES, THEIR USE IN THERAPY AND PROCESS FOR THEIR PREPARATION LABORATOIRE L. LAFON Société anonyme dite: (FR) 1988-01-13 — — EP disclosed
EP-0151702-B1 ALPHA-HYDROXYKETONE ACETALS SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1987-11-25 — — EP disclosed
US-4677228-A Chemical process SMITH KLINE & FRENCH LABORATORIES, LTD. (GB) 1987-06-30 — — US disclosed
EP-0138714-B1 1-(ACETYLAMINOPHENYL)-2-AMINO-PROPANONE DERIVATIVES, THEIR THERAPEUTICAL USE AND PROCESS FOR THEIR PREPARATION LABORATOIRE L. LAFON Société anonyme dite: (FR) 1987-05-20 — — EP disclosed
EP-0192353-A2 Process for the preparation of alkanoylaminophenyl-alkyl ketones SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1986-08-27 — — EP disclosed
EP-0174242-A2 1-(Amino-phenyl)-2-amino propanon derivatives, their use in therapy and process for their preparation LABORATOIRE L. LAFON Société anonyme dite: (FR) 1986-03-12 — — EP disclosed
EP-0151702-A2 Alpha-hydroxyketone acetals SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1985-08-21 — — EP disclosed
EP-0138714-A2 1-(Acetylaminophenyl)-2-amino-propanone derivatives, their therapeutical use and process for their preparation LABORATOIRE L. LAFON Société anonyme dite: (FR) 1985-04-24 — — EP disclosed
EP-0048136-A2 Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1982-03-24 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070208036-A1 Arylalkanes, arylalkenes and aryl-azaalkanes, pharmaceutical compositions containing these compounds and processes for preparing them ARRB1, NPY1R, ADRB3 ALDH1A1 425/4885TP53 4336/4885HIF1A 3983/4885
US-20080058334-A1 Retinoic Acid Mimetic Anilides RXRA, RXRB, RXRG ALDH1A1 187/4885TP53 3898/4885HIF1A 408/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.