Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 12/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159251 | 0.83 | NAMPT (0.39) | NAMPTROCK2HDAC1HDAC2 | |
| SCHEMBL20159442 | 0.81 | NAMPT (0.40) | NAMPTHDAC1HDAC2 | |
| SCHEMBL20159136 | 0.80 | NAMPT (0.37) | NAMPTROCK2HDAC1HDAC2 | |
| SCHEMBL22923600 | 0.80 | ROCK2 (0.54) | NAMPTROCK2 | |
| SCHEMBL20159169 | 0.74 | NAMPT (0.39) | NAMPTROCK2 | |
| SCHEMBL10518939 | 0.74 | PDE3B (0.48) | KCNH2HRH3 | |
| SCHEMBL20159147 | 0.70 | NAMPT (0.39) | NAMPTROCK2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL20159540 | 0.69 | NAMPT (0.38) | NAMPTROCK2 | |
| SCHEMBL20138884 | 0.69 | NAMPT (0.38) | NAMPTROCK2 | |
| SCHEMBL20142989 | 0.69 | NAMPT (0.38) | NAMPTROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |