Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.39 |
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138742 | 0.84 | HRH3 (0.53) | HRH3KCNH2PDE4BSMN1; SMN2PDE3B | |
| SCHEMBL11568277 | 0.84 | HRH3 (0.50) | HRH3KCNH2PDE4BMAPTSMN1; SMN2 | |
| SCHEMBL10518939 | 0.77 | PDE3B (0.48) | HRH3KCNH2MAPTSMN1; SMN2POLB | |
| SCHEMBL10519140 | 0.74 | PDE3B (0.64) | HRH3KCNH2PDE4BPDE3BPDE3A | |
| SCHEMBL6405046 | 0.73 | PDE3B (0.44) | HRH3KCNH2PDE4BPDE3BPDE3A | |
| SCHEMBL8714845 | 0.72 | HRH3 (0.44) | HRH3KCNH2PDE4BPDE3BPDE3A | |
| SCHEMBL20529210 | 0.72 | PDE4B (0.55) | HRH3KCNH2PDE4BPDE3BPDE3A | |
| SCHEMBL21821442 | 0.72 | PDE4B (0.55) | HRH3KCNH2PDE4BPDE3BPDE3A | |
| SCHEMBL927560 | 0.70 | SMN1; SMN2 (0.70) | HRH3KCNH2PDE4BMAPTSMN1; SMN2 | |
| SCHEMBL20142960 | 0.70 | SMN1; SMN2 (0.41) | PDE4BMAPTSMN1; SMN2PDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021013693-A1 | ANTIBODY DRUG CONJUGATES (ADCS) WITH NAMPT INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2021-01-28 | — | — | WO | disclosed |
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |