Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142920 | 0.84 | CYP19A1 (0.45) | SMN1; SMN2MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL20142913 | 0.81 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AGAAMEN1 | |
| SCHEMBL20138995 | 0.80 | PDE4A (0.45) | SMN1; SMN2NPC1RAB9AGAAMEN1 | |
| SCHEMBL20138653 | 0.79 | GAA (0.48) | SMN1; SMN2NPC1RAB9AGAAMEN1 | |
| SCHEMBL20138895 | 0.78 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9AGAAMEN1 | |
| SCHEMBL20138970 | 0.77 | FPR1 (0.37) | SMN1; SMN2NPC1RAB9AGAAMEN1 | |
| SCHEMBL20142942 | 0.77 | PDE4A (0.44) | SMN1; SMN2NPC1RAB9AGAAMEN1 | |
| SCHEMBL20142916 | 0.77 | PDE4B (0.46) | SMN1; SMN2NPC1RAB9AGAAMAPT | |
| SCHEMBL20159360 | 0.76 | NPC1 (0.44) | SMN1; SMN2NPC1RAB9AGAAMEN1 | |
| SCHEMBL20159374 | 0.76 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |