Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.38 |
| ▸ | PDE4A | P27815 | 7/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720176 | 0.81 | NR1H2 (0.41) | HRH3KCNH2 | |
| SCHEMBL8720091 | 0.77 | HRH3 (0.41) | HRH3PDE3BPDE3APDE4BPDE4A | |
| SCHEMBL8303766 | 0.76 | PDE3B (0.51) | KCNH2PDE3BPDE3APDE4BPDE4A | |
| SCHEMBL20138742 | 0.75 | HRH3 (0.53) | HRH3KCNH2PDE3BPDE3APDE4B | |
| SCHEMBL6405046 | 0.73 | PDE3B (0.44) | HRH3KCNH2PDE3BPDE3APDE4B | |
| SCHEMBL20159394 | 0.72 | HRH3 (0.50) | HRH3KCNH2PDE3BPDE3APDE4B | |
| SCHEMBL11568277 | 0.72 | HRH3 (0.50) | HRH3KCNH2PDE3BPDE3APDE4B | |
| SCHEMBL9414700 | 0.70 | PDE3B (0.50) | KCNH2PDE3BPDE3APDE4BPDE4A | |
| SCHEMBL21821442 | 0.69 | PDE4B (0.55) | HRH3KCNH2PDE3BPDE3APDE4B | |
| SCHEMBL20529210 | 0.69 | PDE4B (0.55) | HRH3KCNH2PDE3BPDE3APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |