Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16244413 | 0.81 | RXFP1 (0.45) | RXFP1L3MBTL1TSHRHSD17B10MAPK1 | |
| SCHEMBL20160388 | 0.81 | RXFP1 (0.38) | RXFP1L3MBTL1TSHRHSD17B10MAPK1 | |
| SCHEMBL16259897 | 0.79 | KDM4E (0.47) | RXFP1L3MBTL1KDM4ETSHRHSD17B10 | |
| SCHEMBL16556413 | 0.73 | BRD4 (0.51) | RXFP1L3MBTL1KDM4ETSHRHSD17B10 | |
| SCHEMBL20160352 | 0.73 | CYP1A2 (0.36) | RXFP1L3MBTL1KDM4ETSHRHSD17B10 | |
| SCHEMBL16271636 | 0.72 | RXFP1 (0.40) | RXFP1L3MBTL1KDM4ETSHRHSD17B10 | |
| SCHEMBL20159897 | 0.69 | BRD4 (0.39) | RXFP1L3MBTL1TSHRHSD17B10MAPK1 | |
| SCHEMBL18521190 | 0.68 | RXFP1 (0.36) | RXFP1L3MBTL1TSHRHSD17B10MAPK1 | |
| SCHEMBL24225926 | 0.65 | TGFBR1 (0.38) | RXFP1L3MBTL1KDM4ERAB9AALDH1A1 | |
| SCHEMBL15711661 | 0.64 | RXFP1 (0.47) | RXFP1L3MBTL1KDM4ETSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023178235-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023178234-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2018130227-A1 | AROMATIC RING-CONTAINING COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USE | 山东罗欣药业集团股份有限公司 | 2018-07-19 | — | — | WO | disclosed |
| WO-2018086585-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATIONS THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |