Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 3/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.33 |
| ▸ | EED | O75530 | 2/20 | 0.32 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.32 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.32 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20160785 | 0.75 | IDO1 (0.34) | EZH2CRHR1EEDRBBP4SUZ12 | |
| SCHEMBL20727202 | 0.65 | PDE4B (0.34) | EZH2CRHR1EEDRBBP4SUZ12 | |
| SCHEMBL22479329 | 0.61 | EZH2 (0.38) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL20727144 | 0.60 | EZH2 (0.34) | EZH2CRHR1EEDRBBP4SUZ12 | |
| SCHEMBL28466809 | 0.60 | EZH2 (0.41) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL22479309 | 0.60 | EZH2 (0.41) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL20727204 | 0.59 | EZH2 (0.35) | EZH2CRHR1EEDRBBP4SUZ12 | |
| SCHEMBL13181167 | 0.59 | TACR1 (0.36) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL20160780 | 0.59 | MAPK1 (0.38) | — | |
| SCHEMBL17515853 | 0.59 | IDO1 (0.41) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086589-A1 | 1,5,7-TRI-SUBSTITUTED ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES | 上海海雁医药科技有限公司 | 2018-05-17 | — | — | WO | disclosed |