SCHEMBL20161944

SCHEMBL20161944

CCCCc1c(C)cccc1C(=O)OC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCR5 P32302 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2C19 P33261 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
ALDH1A1 P00352 6/20 0.45
L3MBTL1 Q9Y468 3/20 0.45
HTT P42858 1/20 0.45
NR4A2 P43354 1/20 0.44
RIPK1 Q13546 1/20 0.44
TSHR P16473 4/20 0.44
TDP1 Q9NUW8 1/20 0.44
LMNA P02545 3/20 0.43
MAPK1 P28482 2/20 0.42
TP53 P04637 1/20 0.42
CYP3A4 P08684 1/20 0.42
CFTR P13569 1/20 0.42
HSD17B10 Q99714 1/20 0.42
KMT2A Q03164 2/20 0.42
ALOX12 P18054 1/20 0.42
KDM4E B2RXH2 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8025730 0.95 CXCR5 (0.52) CXCR5CYP1A2CYP2C19SMN1; SMN2ALDH1A1
SCHEMBL19094486 0.86 ALDH1A1 (0.49) CYP1A2CYP2C19SMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL7870569 0.85 ALDH1A1 (0.48) ALDH1A1L3MBTL1HTTNR4A2TSHR
SCHEMBL2180310 0.84 ALDH1A1 (0.48) ALDH1A1L3MBTL1HTTNR4A2TSHR
SCHEMBL4739763 0.83 ALDH1A1 (0.47) ALDH1A1L3MBTL1HTTNR4A2TSHR
Ammonia Solution, Strong SCHEMBL28090259 0.83 ALDH1A1 (0.47) ALDH1A1L3MBTL1HTTNR4A2TSHR
SCHEMBL28638059 0.81 CXCR5 (0.47) CXCR5SMN1; SMN2ALDH1A1L3MBTL1HTT
SCHEMBL6859420 0.81 KDM4E (0.52) CXCR5CYP1A2ALDH1A1L3MBTL1TSHR
SCHEMBL28674480 0.81 TSHR (0.53) CYP1A2CYP2C19SMN1; SMN2ALDH1A1TSHR
SCHEMBL2228895 0.81 CXCR5 (0.53) CXCR5SMN1; SMN2HTTTSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018089261-A2 COMPOUNDS AND METHODS FOR MODULATING INTERLEUKIN-2-INDUCIBLE T-CELL KINASE CORVUS PHARMACEUTICALS, INC. (US) 2018-05-17 WO disclosed