Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10143645 | 0.83 | PDE10A (0.38) | HDAC1PDE10AGRM5NPC1GAA | |
| SCHEMBL17626629 | 0.76 | SUV39H2 (0.44) | HDAC1PDE10AGRM5ADORA3ADORA2A | |
| SCHEMBL12343964 | 0.73 | PDE8B (0.35) | HDAC1PDE10AGRM5NPC1POLB | |
| SCHEMBL12341046 | 0.73 | PDE10A (0.33) | HDAC1PDE10AGRM5NPC1GAA | |
| SCHEMBL20344162 | 0.72 | PDE10A (0.33) | HDAC1PDE10A | |
| SCHEMBL17285646 | 0.72 | HDAC1 (0.35) | HDAC1PDE10A | |
| SCHEMBL25124896 | 0.68 | PDE10A (0.35) | PDE10ANPC1GAAKMT2AKDM4E | |
| SCHEMBL12402544 | 0.68 | PDE10A (0.35) | HDAC1PDE10ANPC1GAAKMT2A | |
| SCHEMBL25044484 | 0.68 | PDE8B (0.39) | PDE10ANPC1GAAKMT2AADORA3 | |
| SCHEMBL25124961 | 0.67 | PDE10A (0.43) | PDE10ANPC1GAAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323821-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | Pfizer Inc (US) | 2018-05-23 | — | — | EP | disclosed |