Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 3/20 | 0.39 |
| ▸ | NOS2 | P35228 | 3/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 6/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | AKT2 | P31751 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17626629 | 0.84 | SUV39H2 (0.44) | PDE8BNOS3NOS2SUV39H2PDE10A | |
| SCHEMBL10143645 | 0.83 | PDE10A (0.38) | PDE8BPDE10AADORA3ADORA2APARP1 | |
| SCHEMBL15101433 | 0.75 | RAB9A (0.59) | PDE10AADORA2ARAB9AKMT2AKDM4E | |
| SCHEMBL17275572 | 0.71 | PDE10A (0.63) | PDE10AADORA2ARAB9AKMT2AKDM4E | |
| SCHEMBL20162086 | 0.68 | HDAC1 (0.35) | PDE10AADORA3ADORA2ARAB9AKMT2A | |
| SCHEMBL7314198 | 0.68 | HTT (0.39) | KDM4EALDH1A1 | |
| SCHEMBL6102107 | 0.67 | ALDH1A1 (0.39) | RAB9AKMT2AKDM4EMEN1NPC1 | |
| SCHEMBL15101432 | 0.67 | PDE10A (0.45) | PDE10ARAB9AKMT2AKDM4EMEN1 | |
| SCHEMBL12343964 | 0.65 | PDE8B (0.35) | PDE8BPDE10ARAB9AKDM4ENPC1 | |
| SCHEMBL12341046 | 0.65 | PDE10A (0.33) | PDE10ARAB9AKMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023018648-A1 | PHENOL DERIVATIVES FOR USE IN THE MODULATION OF BRM | GENENTECH, INC. (US) | 2023-02-16 | — | — | WO | disclosed |