Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 11/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | AADAT | Q8N5Z0 | 3/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16730873 | 0.91 | AADAT (0.41) | IDO1CYP3A4CYP2D6CYP2B6AADAT | |
| SCHEMBL16730872 | 0.88 | IDO1 (0.44) | IDO1PIM1MARK3MAP4K2CAMK2B | |
| SCHEMBL16730871 | 0.80 | PIM1 (0.55) | IDO1PIM1MARK3MAP4K2CAMK2B | |
| SCHEMBL16730879 | 0.78 | IDO1 (0.42) | IDO1CYP3A4CYP2D6CYP2B6CYP11B2 | |
| SCHEMBL20162457 | 0.77 | IDO1 (0.42) | IDO1CYP3A4CYP2D6CYP2B6CYP11B2 | |
| SCHEMBL16730887 | 0.77 | IDO1 (0.42) | IDO1CYP3A4CYP2D6CYP2B6CYP11B2 | |
| SCHEMBL18128804 | 0.75 | FKBP1A (0.44) | IDO1CYP3A4CYP2D6CYP2B6AADAT | |
| SCHEMBL16719008 | 0.75 | FKBP1A (0.44) | IDO1CYP3A4CYP2D6CYP2B6AADAT | |
| SCHEMBL18134517 | 0.75 | IDO1 (0.47) | IDO1PIM1MARK3MAP4K2CAMK2B | |
| SCHEMBL16730949 | 0.75 | IDO1 (0.47) | IDO1PIM1MARK3MAP4K2CAMK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068391-B1 | ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG | MERCK SHARP & DOHME (US) | 2018-05-23 | — | — | EP | claimed |