SCHEMBL20163588

SCHEMBL20163588

Clc1ncc2ccccc2n1.N[SH](=O)=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 2/20 0.38
KDM4E B2RXH2 2/20 0.38
GPR3 P46089 1/20 0.38
CYP1A2 P05177 3/20 0.37
ALDH1A1 P00352 3/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
HTR3A P46098 1/20 0.36
HRH4 Q9H3N8 1/20 0.36
GLA P06280 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35
ACHE P22303 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
NCF1 P14598 1/20 0.35
NOS2 P35228 1/20 0.35
BACE1 P56817 1/20 0.35
PDPK1 O15530 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL149537 0.88 KDM4E (0.46) EGFRKDM4EGPR3CYP1A2ALDH1A1
SCHEMBL29666411 0.88 KDM4E (0.46) EGFRKDM4EGPR3CYP1A2ALDH1A1
SCHEMBL30100747 0.88 KDM4E (0.46) EGFRKDM4EGPR3CYP1A2ALDH1A1
Formaldehyde SCHEMBL27640099 0.86 KDM4E (0.42) EGFRKDM4EGPR3CYP1A2ALDH1A1
Hydrochloric Acid SCHEMBL10524097 0.86 KDM4E (0.45) EGFRKDM4EGPR3CYP1A2ALDH1A1
Biphenyl SCHEMBL28365892 0.81 NPC1 (0.44) EGFRKDM4EGPR3CYP1A2ALDH1A1
Valine SCHEMBL9998032 0.74 SLC7A5 (0.42) KDM4ECYP1A2ALDH1A1SMN1; SMN2RAB9A
SCHEMBL16151415 0.72 SMN1; SMN2 (0.44) KDM4EGPR3CYP1A2ALDH1A1SMN1; SMN2
SCHEMBL29520469 0.70 CYP1A2 (0.44) EGFRKDM4EGPR3CYP1A2ALDH1A1
Quinoline SCHEMBL22734221 0.68 ALDH1A1 (0.74) KDM4ECYP1A2ALDH1A1SMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180140578-A1 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND SELECTIVE TREATMENT OF CANCER BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2018-05-24 US disclosed