SCHEMBL2016376

SCHEMBL2016376

NC(=O)c1cc2c[nH]nc2s1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 4/20 0.49
CSNK2A1 P68400 3/20 0.49
CSNK2A2 P19784 2/20 0.49
CSNK2B P67870 2/20 0.49
HSP90AB1 P08238 1/20 0.46
DAPK3 O43293 3/20 0.44
LIMK1 P53667 3/20 0.44
ROCK1 Q13464 3/20 0.44
CSNK1A1 P48729 2/20 0.44
CLK4 Q9HAZ1 2/20 0.44
DYRK1B Q9Y463 2/20 0.44
TNK2 Q07912 1/20 0.44
CHEK1 O14757 3/20 0.42
AURKA O14965 2/20 0.42
PIM1 P11309 2/20 0.42
FGFR1 P11362 2/20 0.42
PRKACA P17612 2/20 0.42
FLT1 P17948 2/20 0.42
MAPK8 P45983 2/20 0.42
GSK3A P49840 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4592814 0.84 BCL2L1 (0.46) KDRCSNK2A1CSNK2A2CSNK2BDAPK3
Hydrochloric Acid SCHEMBL5981433 0.82 BCL2L1 (0.44) KDRCSNK2A1CSNK2A2CSNK2BDAPK3
SCHEMBL6202716 0.71 ICAM1 (0.45) KDRCSNK2A1CSNK2A2CSNK2BDAPK3
SCHEMBL5235524 0.70 CYP2A6 (0.51) KDRCSNK2A1CSNK2A2CSNK2BHSP90AB1
SCHEMBL27613491 0.69 CYP2A6 (0.50) KDRCSNK2A1CSNK2A2CSNK2BHSP90AB1
Hydrochloric Acid SCHEMBL27655726 0.69 CYP2A6 (0.50) KDRCSNK2A1CSNK2A2CSNK2BHSP90AB1
SCHEMBL13295761 0.68 MAPT (0.71) KDRHSP90AB1DAPK3LIMK1ROCK1
SCHEMBL4073474 0.68 ALDH1A1 (0.33) KDRCSNK2A1CSNK2A2CSNK2BLIMK1
SCHEMBL20722740 0.68 KDR (0.49) KDRCSNK2A1CSNK2A2CSNK2BHSP90AB1
SCHEMBL24164047 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO claimed
EP-2121626-A1 BENZIMIDAZOLE DERIVATIVES Pfizer Products Inc. (US) 2009-11-25 EP claimed
EP-2007380-A2 USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS Nerviano Medical Sciences S.r.l. (IT) 2008-12-31 EP claimed
WO-2008075196-A1 BENZIMIDAZOLE DERIVATIVES PFIZER PRODUCTS INC. (US) 2008-06-26 WO claimed
WO-2007113198-A2 USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2007-10-11 WO claimed
EP-1711177-A1 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS Pfizer Italia S.r.l. (IT) 2006-10-18 EP claimed
WO-2005074922-A1 1H-THIENO[2,3-c]PYRAZOLE DERIVATIVES USEFUL AS KINASE INHIBITORS PFIZER ITALIA S.R.L. (IT) 2005-08-18 WO claimed
WO-2025042956-A1 PDE 7 MODULATOR COMPOUNDS OMEROS CORPORATION (US) 2025-02-27 WO disclosed
CN-102827082-B Thienopyrazole derivative having PDE7 inhibitory activity DAIICHI SANKYO CO LTD 2015-01-07 CN disclosed
WO-2014102497-A1 DERMATOLOGICAL COMPOSITION COMPRISING A PDE7 INHIBITOR IN A SOLUBILISED FORM, PRODUCTION METHOD THEREOF, AND USE OF SAME GALDERMA RESEARCH & DEVELOPMENT (FR) 2014-07-03 WO disclosed
WO-2014102498-A1 DERMATOLOGICAL COMPOSITION COMPRISING A PDE7 INHIBITOR IN A DISPERSED FORM, METHOD FOR THE PRODUCTION THEREOF, AND USE OF SAME GALDERMA RESEARCH & DEVELOPMENT (FR) 2014-07-03 WO disclosed
CN-102827082-A Thienopyrazole derivative having PDE7 inhibitory activity DAIICHI SANKYO CO LTD 2012-12-19 CN disclosed
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO disclosed
EP-1711177-A1 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS Pfizer Italia S.r.l. (IT) 2006-10-18 EP disclosed
WO-2006092510-A1 HYDRAZINOCARBONYL-THIENO[2,3-C]PYRAZOLES, PREPARATION METHOD, COMPOSITIONS CONTAINING SAME AND USE AVENTIS PHARMA S.A. (FR) 2006-09-08 WO disclosed
WO-2005074922-A1 1H-THIENO[2,3-c]PYRAZOLE DERIVATIVES USEFUL AS KINASE INHIBITORS PFIZER ITALIA S.R.L. (IT) 2005-08-18 WO disclosed
EP-1534716-A1 HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS Pharmacia Italia S.p.A. (IT) 2005-06-01 EP disclosed
EP-1530573-A1 CONDENSED HETEROCYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS Pharmacia Italia S.p.A. (IT) 2005-05-18 EP disclosed
WO-2004013146-A1 CONDENSED HETEROCYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA S.P.A (IT) 2004-02-12 WO disclosed
WO-2004007504-A1 HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA S.P.A. (IT) 2004-01-22 WO disclosed