Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 12/20 | 0.45 |
| ▸ | SELE | P16581 | 12/20 | 0.45 |
| ▸ | VCAM1 | P19320 | 7/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 4/20 | 0.42 |
| ▸ | PRKACA | P17612 | 4/20 | 0.42 |
| ▸ | GSK3A | P49840 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.42 |
| ▸ | CDK8 | P49336 | 4/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.42 |
| ▸ | CLK2 | P49760 | 3/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179034 | 0.84 | GPR35 (0.42) | ICAM1SELEVCAM1KDRCSNK2A1 | |
| SCHEMBL12545252 | 0.79 | CSNK2A2 (0.51) | ICAM1SELEVCAM1KDRCSNK2A1 | |
| SCHEMBL2016376 | 0.71 | KDR (0.49) | ICAM1SELEVCAM1KDRCSNK2A1 | |
| SCHEMBL27387346 | 0.69 | — | — | |
| SCHEMBL31108975 | 0.67 | GRIN3B (0.56) | ICAM1SELEVCAM1KDRCSNK2A1 | |
| SCHEMBL15319398 | 0.67 | ICAM1 (0.55) | ICAM1SELEVCAM1KDRCSNK2A1 | |
| SCHEMBL31533914 | 0.67 | ICAM1 (0.55) | ICAM1SELEVCAM1KDRCSNK2A1 | |
| SCHEMBL1217553 | 0.67 | GRIN3B (0.56) | ICAM1SELEVCAM1KDRCSNK2A1 | |
| SCHEMBL30250552 | 0.64 | GDA (0.43) | ICAM1SELEVCAM1KDRCSNK2A1 | |
| SCHEMBL1725437 | 0.64 | LCK (0.46) | PKN2KMT2ACHEK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534716-A1 | HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004007504-A1 | HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2004-01-22 | — | — | WO | disclosed |