Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.65 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018296 | 1.00 | HCRTR1 (0.65) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2016348 | 0.88 | HCRTR1 (0.61) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2052690 | 0.88 | HCRTR1 (0.61) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2015020 | 0.88 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2012310 | 0.86 | HCRTR1 (0.67) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL13139074 | 0.85 | HCRTR1 (0.84) | HCRTR1HCRTR2NPC1RAB9AMEN1 | |
| SCHEMBL13139077 | 0.85 | HCRTR1 (0.75) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2015025 | 0.85 | HCRTR1 (0.70) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2052111 | 0.84 | HCRTR1 (0.67) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2014060 | 0.84 | HCRTR1 (0.67) | HCRTR1HCRTR2NPC1RAB9AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |