Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 5/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.56 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.56 |
| ▸ | CHRNA2 | Q15822 | 3/20 | 0.56 |
| ▸ | CHRNG | P07510 | 2/20 | 0.56 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.56 |
| ▸ | CHRND | Q07001 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3058805 | 0.93 | CHRNB2 (0.62) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL3058809 | 0.93 | CHRNB2 (0.62) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL17264284 | 0.93 | CHRNB2 (0.62) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL31019621 | 0.91 | CHRNB4 (0.64) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL30866535 | 0.91 | CHRNB4 (0.64) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL159158 | 0.91 | CHRNB4 (0.64) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL159159 | 0.91 | CHRNB4 (0.64) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| Acetic Acid SCHEMBL27199916 | 0.83 | CHRNB4 (0.56) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| Acetic Acid SCHEMBL31344159 | 0.83 | CHRNB4 (0.56) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL17258323 | 0.82 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200236936-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2020-07-30 | — | — | US | disclosed |
| US-10667515-B2 | (S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190200611-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2019-07-04 | — | — | US | disclosed |
| US-20180139961-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10667515-B2 | (S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using | AAAS, NANS, CIAPIN1 | CHRNB4 2085/4885CHRNA3 2431/4885CHRNB2 2259/4885 |
| US-20190200611-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | AAAS, NANS, CIAPIN1 | CHRNB4 2085/4885CHRNA3 2431/4885CHRNB2 2259/4885 |
| US-20200236936-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | AAAS, NANS, CIAPIN1 | CHRNB4 2085/4885CHRNA3 2431/4885CHRNB2 2259/4885 |
| US-20180139961-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | AAAS, NANS, CIAPIN1 | CHRNB4 2085/4885CHRNA3 2431/4885CHRNB2 2259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.