Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12491178 | 0.89 | BCL2 (0.47) | TAAR1BCL2PIK3CDNOTUMKDM4E | |
| SCHEMBL2016661 | 0.89 | PIK3CD (0.36) | TAAR1BCL2PIK3CDNOTUMKDM4E | |
| SCHEMBL2014788 | 0.84 | TAAR1 (0.43) | TAAR1PIK3CDKDM4ESYKHTR2A | |
| Trifluoroacetic Acid SCHEMBL2012078 | 0.81 | BCL2 (0.41) | TAAR1BCL2PIK3CDCYP3A4GRIN2B | |
| SCHEMBL12403232 | 0.79 | BCL2 (0.48) | TAAR1BCL2PIK3CDNOTUMKDM4E | |
| SCHEMBL2015599 | 0.78 | BCL2 (0.36) | TAAR1BCL2PIK3CDHTR2AMPO | |
| SCHEMBL2016719 | 0.78 | PIK3CD (0.47) | TAAR1BCL2PIK3CDSYK | |
| SCHEMBL2019261 | 0.77 | PIK3CD (0.44) | BCL2PIK3CDNOTUMKDM4ECYP17A1 | |
| SCHEMBL2016428 | 0.77 | BCL2 (0.48) | TAAR1BCL2PIK3CDNOTUMKDM4E | |
| SCHEMBL12631928 | 0.76 | PIK3CD (0.47) | TAAR1BCL2PIK3CDNOTUMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |