SCHEMBL20166486

SCHEMBL20166486

O=C1CCC2(CCNCC2)C1=O

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 1/20 0.45
NEK2 P51955 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18838403 0.75 CRBN (0.48) CRBNNEK2
SCHEMBL873015 0.75 CDC7 (0.40)
SCHEMBL21627721 0.70
SCHEMBL22018269 0.70 CRBN (0.77) CRBNNEK2
SCHEMBL2514647 0.69 BACE1 (0.38) CRBN
SCHEMBL1912704 0.69 SIGMAR1 (0.64)
SCHEMBL31566947 0.67
SCHEMBL29750045 0.67
SCHEMBL2169285 0.67 CRBN (0.41) CRBNNEK2
Hydrochloric Acid SCHEMBL6975774 0.65 CRBN (0.39) CRBNNEK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024072178-A1 COMPOUND FOR TARGETED PROTEIN DEGRADATION, AND USE THEREOF (주)사이러스테라퓨틱스 2024-04-04 WO disclosed
EP-3541790-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE Temple University - Of The Commonwealth System of Higher Education (US) 2019-09-25 EP disclosed
WO-2018093818-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2018-05-24 WO disclosed