Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016383 | 0.88 | PPARG (0.40) | KMT2APPARGMEN1PKMGAA | |
| SCHEMBL3054151 | 0.84 | PPARG (0.42) | KDM4ERAD52PTGER4KMT2APPARG | |
| SCHEMBL2014360 | 0.84 | PPARG (0.45) | KDM4ERAD52PTGER4KMT2APPARG | |
| SCHEMBL9931328 | 0.82 | KDM4E (0.49) | KDM4EKMT2APPARGHTTCYP1A2 | |
| SCHEMBL14250115 | 0.82 | MEN1 (0.54) | PTGER4KMT2ATDP1MEN1PKM | |
| SCHEMBL14369083 | 0.79 | KDM4E (0.64) | KDM4ERAD52PTGER4KMT2ATDP1 | |
| SCHEMBL8292031 | 0.77 | CYP1A2 (0.64) | KDM4EKMT2AMEN1PKMGAA | |
| SCHEMBL10176981 | 0.77 | JAK2 (0.52) | PPARGHDAC6HTTHDAC1MAPT | |
| SCHEMBL13497694 | 0.76 | AAK1 (0.49) | KDM4ERAD52PTGER4KMT2ATDP1 | |
| SCHEMBL4979115 | 0.76 | KMT2A (0.57) | KMT2ATDP1MEN1PKMCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |