Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | NPM1 | P06748 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016798 | 0.88 | KDM4E (0.44) | PPARGMEN1KMT2APKMHTT | |
| SCHEMBL25421051 | 0.84 | NPM1 (0.36) | PPARGMEN1KMT2AMAPTNPM1 | |
| SCHEMBL2013679 | 0.84 | PPARG (0.45) | PPARGMEN1KMT2APKMHTT | |
| SCHEMBL22031586 | 0.82 | GLA (0.49) | PPARGMEN1KMT2APKM | |
| SCHEMBL24329871 | 0.81 | MAPT (0.45) | PPARGMEN1KMT2AHTTMAPT | |
| SCHEMBL16406373 | 0.79 | ACSS2 (0.53) | MEN1KMT2APKMCYP1A2CYP2D6 | |
| SCHEMBL21803208 | 0.79 | KDM4E (0.51) | KMT2AHTTCYP1A2MAPTSMN1; SMN2 | |
| SCHEMBL28095051 | 0.78 | CYP11B1 (0.41) | PPARGMEN1KMT2AHTTCYP1A2 | |
| SCHEMBL8292031 | 0.77 | CYP1A2 (0.64) | MEN1KMT2APKMHTTCYP1A2 | |
| SCHEMBL20209144 | 0.77 | ACSS2 (0.57) | MEN1KMT2AHTTMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |