Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013679 | 0.88 | PPARG (0.45) | PPARGALDH1A1LMNATP53MAPK1 | |
| SCHEMBL3054151 | 0.84 | PPARG (0.42) | PPARGALDH1A1LMNATP53MAPK1 | |
| SCHEMBL2016798 | 0.84 | KDM4E (0.44) | PPARGALDH1A1TP53MAPK1HDAC6 | |
| SCHEMBL14250115 | 0.82 | MEN1 (0.54) | ALDH1A1LMNATP53PTGER4GAA | |
| SCHEMBL6247270 | 0.81 | MAPK1 (0.50) | ALDH1A1LMNATP53MAPK1HDAC1 | |
| SCHEMBL31569633 | 0.81 | MAPT (0.49) | PPARGALDH1A1LMNATP53MAPK1 | |
| SCHEMBL12290596 | 0.80 | CNR2 (0.48) | — | |
| SCHEMBL9979897 | 0.79 | LMNA (0.49) | PPARGALDH1A1LMNATP53MAPK1 | |
| SCHEMBL14369083 | 0.79 | KDM4E (0.64) | LMNAPTGER4KDM4ERAD52GAA | |
| SCHEMBL1972515 | 0.78 | ALDH1A1 (0.40) | PPARGALDH1A1LMNATP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |