SCHEMBL20168145

SCHEMBL20168145

O=C(O)COc1cc(C(F)(F)F)ccc1CN1CCCC12CCNCC2

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 14/20 0.70
FAAH O00519 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL22409695 0.99 MGLL (0.69) MGLLFAAH
SCHEMBL29446985 0.85 MGLL (0.56) MGLLFAAH
SCHEMBL20168397 0.85 MGLL (0.56) MGLLFAAH
SCHEMBL25802776 0.85 MGLL (0.51) MGLL
SCHEMBL20182525 0.83 MGLL (0.77) MGLL
SCHEMBL20166493 0.83 MGLL (1.00) MGLL
Hydrochloric Acid SCHEMBL22409693 0.82 MGLL (0.69) MGLLFAAH
SCHEMBL20182411 0.82 MGLL (0.69) MGLLFAAH
Hydrochloric Acid SCHEMBL29446983 0.82 MGLL (0.69) MGLLFAAH
SCHEMBL22350712 0.80 MGLL (0.45) MGLLFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3541820-B1 MAGL INHIBITORS H LUNDBECK AS (DK) 2023-07-05 EP disclosed
US-11691975-B2 MAGL inhibitors H. LUNDBECKA/S (DK) 2023-07-04 US disclosed
US-20220135563-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2022-05-05 US disclosed
US-11059822-B2 MAGL inhibitors H. LUNDBECK A/S (DK) 2021-07-13 US disclosed
US-20200291023-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2020-09-17 US disclosed
EP-3541820-A1 MAGL INHIBITORS Abide Therapeutics, Inc. (US) 2019-09-25 EP disclosed
WO-2018093949-A1 MAGL INHIBITORS ABIDE THERAPEUTICS, INC. (US) 2018-05-24 WO disclosed
WO-2018093949-A1 MAGL INHIBITORS ABIDE THERAPEUTICS, INC. (US) 2018-05-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11059822-B2 MAGL inhibitors MAG, MAGI3, MGLL MGLL 3/4885FAAH 29/4885
US-20220135563-A1 MAGL INHIBITORS MAG, MAGI3, MGLL MGLL 3/4885FAAH 29/4885
US-20200291023-A1 MAGL INHIBITORS MAG, MAGI3, MGLL MGLL 3/4885FAAH 29/4885
US-11691975-B2 MAGL inhibitors MAG, MAGI3, MGLL MGLL 3/4885FAAH 29/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.