Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.46 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.44 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.44 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.44 |
| ▸ | OTC | P00480 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.39 |
| ▸ | RRM1 | P23921 | 1/20 | 0.39 |
| ▸ | ARG2 | P78540 | 4/20 | 0.37 |
| ▸ | ARG1 | P05089 | 3/20 | 0.37 |
| ▸ | NOS2 | P35228 | 3/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20168409 | 1.00 | DPP7 (0.46) | DPP7GNAI3GNAO1GNAI1OTC | |
| SCHEMBL20951925 | 0.94 | OTC (0.46) | DPP7GNAI3GNAO1GNAI1OTC | |
| SCHEMBL9875639 | 0.86 | GSR (0.57) | DPP7GNAI3GNAO1GNAI1OTC | |
| SCHEMBL20643482 | 0.86 | GSR (0.57) | DPP7GNAI3GNAO1GNAI1OTC | |
| SCHEMBL357483 | 0.86 | GSR (0.57) | DPP7GNAI3GNAO1GNAI1OTC | |
| SCHEMBL23111902 | 0.85 | ALOX15 (0.37) | DPP7OTCGSRDDAH1NOS2 | |
| SCHEMBL23111901 | 0.85 | ALOX15 (0.37) | DPP7OTCGSRDDAH1NOS2 | |
| SCHEMBL19744548 | 0.83 | DPP7 (0.39) | DPP7GNAI3GNAO1GNAI1OTC | |
| SCHEMBL21467496 | 0.82 | DPP7 (0.44) | DPP7GNAI3GNAO1GNAI1OTC | |
| SCHEMBL16285441 | 0.82 | KDM4E (0.56) | DPP7GNAI3GNAO1GNAI1RRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094335-A1 | FINE-TUNE MODULATORS OF NEURONAL EXCITABILITY FOR NEUROPSYCHIATRIC DISORDERS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-05-24 | — | — | WO | disclosed |