Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | GLS | O94925 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20136969 | 0.82 | MAOB (0.40) | MAOBKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20087393 | 0.80 | PTGS1 (0.42) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL14485049 | 0.73 | MAOB (0.65) | MAOBCA12CA9ALDH1A1ACHE | |
| SCHEMBL2569807 | 0.73 | ALDH1A1 (0.59) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4952752 | 0.71 | MAOB (0.62) | MAOBCA12CA9ALDH1A1SMN1; SMN2 | |
| SCHEMBL24218467 | 0.71 | MAOB (0.53) | MAOBCA12CA9GLSKMT2A | |
| SCHEMBL135305 | 0.70 | CA12 (0.66) | CA12CA9KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL30098360 | 0.70 | CA12 (0.66) | CA12CA9KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL30839875 | 0.70 | HEXA (0.72) | MAOBGLSACHE | |
| SCHEMBL13590076 | 0.70 | HEXA (0.72) | MAOBGLSACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541821-A1 | MAGL INHIBITORS | Abide Therapeutics, Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018093947-A1 | MAGL INHIBITORS | ABIDE THERAPEUTICS, INC. (US) | 2018-05-24 | — | — | WO | disclosed |