Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.49 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 8/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012713 | 0.93 | PIK3CD (0.55) | PIK3CDBCL2AURKARPS6KB1AURKB | |
| SCHEMBL2016865 | 0.85 | PIK3CD (0.56) | PIK3CDBCL2AURKAAURKBMAP4K4 | |
| SCHEMBL2051059 | 0.83 | PIK3CD (0.53) | PIK3CDBCL2AURKAAURKBMAP4K4 | |
| Trifluoroacetic Acid SCHEMBL2050998 | 0.83 | PIK3CD (0.40) | PIK3CDBCL2 | |
| Trifluoroacetic Acid SCHEMBL2013841 | 0.80 | BCL2 (0.42) | PIK3CDBCL2LRRK2NR1H2 | |
| SCHEMBL2038100 | 0.80 | PIK3CD (0.41) | PIK3CDBCL2AURKARPS6KB1AURKB | |
| Trifluoroacetic Acid SCHEMBL2012078 | 0.79 | BCL2 (0.41) | PIK3CDBCL2LRRK2NR1H2 | |
| Trifluoroacetic Acid SCHEMBL2052496 | 0.78 | PIK3CD (0.35) | PIK3CDRPS6KB1 | |
| SCHEMBL2012486 | 0.77 | PIK3CD (0.46) | PIK3CDBCL2 | |
| SCHEMBL2016719 | 0.77 | PIK3CD (0.47) | PIK3CDBCL2AURKARPS6KB1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680108-B2 | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors | INCYTE CORPORATION (US) | 2014-03-25 | — | — | US | disclosed |
| US-20110183985-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION | 2011-07-28 | — | — | US | disclosed |
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183985-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | PIK3R1, PIK3R3, PIK3R2 | PIK3CD 13/4885BCL2 1174/4885AURKA 792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.