Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.56 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 8/20 | 0.41 |
| ▸ | ASAH2 | Q9NR71 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13896121 | 0.91 | SPHK1 (0.57) | SPHK1SPHK2AHRNR5A1APP | |
| SCHEMBL23519670 | 0.90 | SPHK1 (0.46) | SPHK1SPHK2AHRNR5A1PLA2G4B | |
| SCHEMBL12450356 | 0.90 | SPHK1 (0.70) | SPHK1SPHK2AHRNR5A1APP | |
| SCHEMBL20905106 | 0.87 | SPHK1 (0.70) | SPHK1SPHK2AHRAPPABCG2 | |
| SCHEMBL20168989 | 0.85 | SPHK1 (0.77) | SPHK1SPHK2ASAH2 | |
| SCHEMBL20609508 | 0.83 | ASAH2 (0.43) | SPHK1SPHK2PLA2G4BASAH2ABCG2 | |
| SCHEMBL23519671 | 0.81 | SPHK1 (0.55) | SPHK1SPHK2AHRNR5A1PLA2G4B | |
| SCHEMBL12812128 | 0.80 | SPHK1 (0.51) | SPHK1SPHK2AHRNR5A1PLA2G4B | |
| SCHEMBL18194576 | 0.79 | SPHK1 (0.52) | SPHK1SPHK2AHRNR5A1PLA2G4B | |
| SCHEMBL12450354 | 0.79 | SPHK1 (0.52) | SPHK1SPHK2AHRNR5A1PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9974758-B2 | Sphingosine kinase type 1 inhibitors and uses thereof | ENZO THERAPEUTICS, INC. (US) | 2018-05-22 | — | — | US | disclosed |