Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.46 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.40 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | ASAH2 | Q9NR71 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.38 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20168979 | 0.90 | SPHK1 (0.56) | SPHK1SPHK2AHRNR5A1PLA2G4B | |
| SCHEMBL13896121 | 0.81 | SPHK1 (0.57) | SPHK1SPHK2AHRCYP1A2CYP19A1 | |
| SCHEMBL20609508 | 0.81 | ASAH2 (0.43) | SPHK1SPHK2PLA2G4BASAH2ABCG2 | |
| SCHEMBL12450356 | 0.81 | SPHK1 (0.70) | SPHK1SPHK2AHRNR5A1ABCG2 | |
| SCHEMBL12812128 | 0.78 | SPHK1 (0.51) | SPHK1SPHK2AHRCYP1A2CYP19A1 | |
| SCHEMBL20905106 | 0.78 | SPHK1 (0.70) | SPHK1SPHK2AHRCYP1A2CYP19A1 | |
| SCHEMBL12450354 | 0.77 | SPHK1 (0.52) | SPHK1SPHK2AHRCYP1A2CYP19A1 | |
| SCHEMBL18194576 | 0.77 | SPHK1 (0.52) | SPHK1SPHK2AHRCYP1A2CYP19A1 | |
| SCHEMBL20168989 | 0.76 | SPHK1 (0.77) | SPHK1SPHK2CYP2C9ASAH2 | |
| SCHEMBL20651372 | 0.75 | LTA4H (0.46) | SPHK1SPHK2AHRNR5A1PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11737992-B2 | Sphingosine kinase Type 1 inhibitors and uses thereof | ENZO THERAPEUTICS, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| US-20210177776-A1 | SPHINGOSINE KINASE TYPE 1 INHIBITORS AND USES THEREOF | ENZO THERAPEUTICS, INC. (US) | 2021-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210177776-A1 | SPHINGOSINE KINASE TYPE 1 INHIBITORS AND USES THEREOF | SPHK1, SPHK2, S1PR1 | SPHK1 1/4885SPHK2 2/4885AHR 4728/4885 |
| US-11737992-B2 | Sphingosine kinase Type 1 inhibitors and uses thereof | SPHK1, SPHK2, S1PR1 | SPHK1 1/4885SPHK2 2/4885AHR 4728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.