Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 14/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20169369 | 0.92 | DGAT1 (0.38) | DGAT1PTGS2PTGS1 | |
| SCHEMBL20169325 | 0.90 | DGAT1 (0.47) | DGAT1PTGS2PTGS1 | |
| SCHEMBL20169380 | 0.89 | DGAT1 (0.46) | DGAT1PTGS2PTGS1 | |
| SCHEMBL20169368 | 0.89 | DGAT1 (0.46) | DGAT1PTGS2PTGS1 | |
| SCHEMBL20169378 | 0.87 | DGAT1 (0.45) | DGAT1PTGS2PTGS1 | |
| SCHEMBL9940375 | 0.87 | DGAT1 (0.61) | DGAT1PTGS2PTGS1RXRANR1H2 | |
| SCHEMBL17772387 | 0.85 | DGAT1 (0.43) | DGAT1PTGS2 | |
| SCHEMBL20169353 | 0.85 | DGAT1 (0.52) | DGAT1PTGS2PTGS1RXRANR1H2 | |
| SCHEMBL20169321 | 0.84 | DGAT1 (0.56) | DGAT1PTGS2PTGS1 | |
| SCHEMBL20169323 | 0.83 | DGAT1 (0.47) | DGAT1PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975871-B2 | Continuous arycyclic compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2018-05-22 | — | — | US | disclosed |