SCHEMBL2011905

SCHEMBL2011905

CN(C(=O)c1c[nH]c2ccccc12)C(CCNC(=O)c1cccn1C)Cc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.61
HCRTR2 O43614 2/20 0.61
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
ACHE P22303 1/20 0.41
HAT1 O14929 1/20 0.40
EP300 Q09472 1/20 0.40
GABRP O00591 1/20 0.40
GABRD O14764 1/20 0.40
GABRA1 P14867 1/20 0.40
GABRB1 P18505 1/20 0.40
GABRG2 P18507 1/20 0.40
GABRB3 P28472 1/20 0.40
GABRA5 P31644 1/20 0.40
GABRA3 P34903 1/20 0.40
GABRA2 P47869 1/20 0.40
GABRB2 P47870 1/20 0.40
GABRA4 P48169 1/20 0.40
GABRE P78334 1/20 0.40
GABRA6 Q16445 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2054164 1.00 HCRTR1 (0.61) HCRTR1HCRTR2NPC1RAB9AACHE
SCHEMBL2013188 0.90 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2016933 0.88 HCRTR1 (0.60) HCRTR1HCRTR2NPC1RAB9A
SCHEMBL13139060 0.85 HCRTR1 (0.77) HCRTR1HCRTR2NPC1RAB9AKMT2A
SCHEMBL2013812 0.84 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2012147 0.84 HCRTR1 (0.61) HCRTR1HCRTR2NPC1RAB9AACHE
SCHEMBL2051271 0.84 HCRTR1 (0.61) HCRTR1HCRTR2NPC1RAB9AACHE
SCHEMBL2014119 0.82 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9AKMT2A
SCHEMBL2011844 0.82 HCRTR1 (0.60) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2014804 0.82 HCRTR1 (0.58) HCRTR1HCRTR2NPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO claimed
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO disclosed